Information
Technologies Innovation


Supported by:
Bioinformatics Applications for microorganisms analyses

The bioinformatics Applications for microorganisms analyses project is focused on performing computational analysis of mutations of hepatitis C virus (HCV) associated with resistance to direct-acting antiviral (DAA). Chronic HCV infection remains a serious public health problem worldwide, affecting 200 million people and causing about 10,000 deaths annually. It is therefore important to determine the variability of the HCV NS3, NS5A and NS5B genes, the target of DAA, to determine their potential impact on new DAA therapy in patients infected with HCV, to prevent potential therapeutic failures and to optimize future treatment regimens choosing the most appropriate DAA for each patient.

  • Start Date: 2013-01-01
  • Authors
    • Hector Florez
    • Karina Salvatierra
  • Software
    • PSSA
    • BMA
  • Publications
        • Journal Papers
          1. Sweta Singh, Hector Florez. Coronavirus disease 2019 drug discovery through molecular docking. F1000 Research. ISSN:2046-1402. vol:9(502). p:1-9. (2020).
          2. Hector Florez, Sweta Singh. Online dashboard and data analysis approach for assessing COVID-19 case and death data. F1000 Research. ISSN:2046-1402. vol:9(570). p:1-9. (2020).
          3. Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. Communications in Computer and Information Science. ISSN:1865-0929. vol:1051. p:3-14. (2019).
          4. Salvatierra Karina, Florez Hector. Bioinformatics Approach to Analyze Influenza Viruses. Communications in Computer and Information Science. ISSN:1865-0929. vol:916. p:442-452. (2018).
          5. Guardiola Mauro, Salvatierra Karina, Florez Hector. Computer analysis of resistance mutations to HCV NS5A antivirals. International Journal of Infectious Diseases. ISSN:1201-9712. vol:73S. p:382-383. (2018).
          6. Salvatierra Karina, Florez Hector. Computational analysis of resistance mutations in the hepatitis C virus. Vínculos. ISSN:1794-211X. vol:15. p:27-33. (2018).
          7. Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. Communications in Computer and Information Science. ISSN:1865-0929. vol:742. p:96-107. (2017).
          8. Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. Information. ISSN:1343-4500. vol:20 (9A). p:6665-6672. (2017).
          9. Salvatierra Karina, Florez Hector. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. F1000 Research. ISSN:2046-1402. vol:6 (21). p:1-8. (2017).
          10. Salvatierra Karina, Florez Hector. Prevalence of hepatitis B and C infections in hemodialysis patients. F1000 Research. ISSN:2046-1402. vol:5 (1910). p:1-6. (2016).
          11. Salvatierra Karina, Florez Hector. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. F1000 Research. ISSN:2046-1402. vol:5 (1141). p:1-9. (2016).
          12. Salvatierra Karina, Florez Hector. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. Infectio. ISSN:0123-9392. vol:20 (3). p:130-137. (2015).
          13. Salvatierra Karina, Florez Hector. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. Biomédica. ISSN:0120-4157. vol:35. p:125. (2015).
        • Academic Conferences
          1. Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. p:3-14. Madrid, Spain. (2019).
          2. Salvatierra Karina, Vera Marcos, Lloret María Antonia, Florez Hector. In Silico Docking Study: Antiviral Activity of Sofosbuvir Against NS5 Protein from Sika Virus. Buenos Aires, Argentina. (2018).
          3. Salvatierra Karina, Florez Hector, Lopez Labrador Xavier. Coevolution Analysis of Proteins NS3 and NS5B of Hepatitis C Virus in Geotype 1B Isolates. Santiago, Chile. (2018).
          4. Salvatierra Karina, Florez Hector. Bioinformatics Approach to Analyze Influenza Viruses. p:442-452. Medellin, Colombia. (2018).
          5. Guardiola Mauro, Salvatierra Karina, Florez Hector. Computer analysis of resistance mutations to HCV NS5A antivirals. p:382-383. Buenos Aires, Argentina. (2018).
          6. Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. p:96-107. Cartagena, Colombia. (2017).
          7. Florez Hector, Salvatierra Karina. Using bioinformatics methods to analyze influenza viruses. p:65-72. Toronto, Canada. (2017).
          8. Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. p:6665-6672. Bandung, Indonesia. (2017).
          9. Florez Hector, Salvatierra Karina. Computational analysis of resistance mutations to new direct acting antivirals in the Hepatitis C virus. p:65-66. Madison, United States. (2017).
          10. Florez Hector, Salvatierra Karina. Computational analysis of E1 gene of chikungunya virus to identify genotypes. p:60-61. Madison, United States. (2017).
          11. Florez Hector, Salvatierra Karina. A Tool for Analyzing Mutations in Biomedical Microorganisms. p:25-33. Orlando, United States. (2017).
          12. Salvatierra Karina, Florez Hector. Hepatitis C virus NS3 protease resistance testing: analysis computational to detect resistance mutations. p:6. Hyderabad, India. (2016).
          13. Salvatierra Karina, Florez Hector. Computational analysis to detect resistance mutations to direct acting antivirals in Hepatitis C virus. p: 47. San Jose, Costa Rica. (2016).
          14. Florez Hector, Salvatierra Karina. Análisis computacional de mutaciones de resistencias del virus de la hepatitis C. p:21. Buenos Aires, Argentina. (2015).
          15. Salvatierra Karina, Florez Hector. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. p:125. Bogota, Colombia. (2015).

        Solutions design in the context of model driven engineering

        Through the creation of metamodels and model to model and model-to-text transformations, it is desirable to create software projects almost automatically, from the creation of a single conceptual model.

        • Start Date: 2013-01-01
        • Authors
          • Hector Florez
          • Daniel Sanchez
          • Oscar Mendez
        • Software
          • CFP
          • RIS
          • DevPHP
          • RIWA
          • PHPGen
        • Publications
          • Books
            1. Florez Hector. Sistemas Digitales. Ediciones de la U. ISSN:978-958-762-190-7. 2014.
          • Book Chapters
            1. Florez, Hector. Human Factors in Automated Analysis for Enterprise Models. IGI Global. ISSN:180619075135. 2019.
            2. Florez Hector, Sanchez Mario, Villalobos Jorge. Drafting Enterprise Models. IGI Global. ISSN:9781522555223. 2018.
          • Journal Papers
            1. Florez Hector, Garcia Edwarth, Muñoz Deisy. Automatic Code Generation System for Transactional Web Applications. Lecture Notes in Computer Science. ISSN:0302-9743. vol:11623. p:436-451. (2019).
            2. Florez Hector, Leon Marcelo. Model Driven Engineering Approach to Configure Software Reusable Components. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:352-363. (2018).
            3. Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
            4. Sanchez Daniel, Mendez Oscar, Florez Hector. An Approach of a Framework to Create Web Applications. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:341-352. (2018).
            5. Florez Hector, Sanchez Mario, Villalobos Jorge. Analysis of Imprecise Enterprise Models. Lecture Notes in Business Information Processing. ISSN:1865-1348. vol:248. p:349-364. (2016).
            6. Florez Hector, Sanchez Mario, Villalobos Jorge. A Catalog of Automated Analysis Methods for Enterprise Models. SpringerPlus. ISSN:2193-1801. vol:5 (406). p:1-24. (2016).
            7. Florez Hector. Metamodels composition strategy for the model driven engineering context. Vínculos. ISSN:1794-211X. vol:44. p:109-120. (2015).
            8. Gomez Paola, Sanchez Mario, Florez Hector, Villalobos Jorge. An Approach to the Co-creation of Models and Metamodels in Enterprise Architecture Projects. Journal of Object Technology. ISSN:1660-1769. vol:13 (3). p:1-29. (2014).
            9. Florez Hector, Sanchez Mario, Villalobos Jorge. Embracing Imperfection in Enterprise Architecture Models. CEUR Workshops Proceedings. ISSN:1613-0073. vol:1023. p:8-17. (2013).
            10. Florez Hector. Adapting models in metamodels composition processes. Vínculos. ISSN:1794-211X. vol:10 (1). p:96-108. (2013).
          • Academic Conferences
            1. Florez Hector, Garcia Edwarth, Muñoz Deisy. Automatic Code Generation System for Transactional Web Applications. p:436-451. Saint Petesburg, Russia. (2019).
            2. Florez Hector, Leon Marcelo. Model Driven Engineering Approach to Configure Software Reusable Components. p:352-363. Bogota, Colombia. (2018).
            3. Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
            4. Sanchez Daniel, Mendez Oscar, Florez Hector. An Approach of a Framework to Create Web Applications. p:341-352. Melbourne, Australia. (2018).
            5. Sanchez Daniel, Mendez Oscar, Florez Hector. Applying the 3-layer Model in the Construction of a Framework to Create Web Applications. p:364-369. Orlando, United States. (2017).
            6. Florez Hector, Sanchez Mario, Villalobos Jorge. Analysis of Imprecise Enterprise Models. p:349-364. Ljubljana, Slovenia. (2016).
            7. Florez Hector, Sanchez Mario, Villalobos Jorge. Extensible Model-based Approach for Supporting Automatic Enterprise Analysis. p:32-41. Ulm, Germany. (2014).
            8. Florez Hector, Sanchez Mario, Villalobos Jorge. iArchiMate: A Tool for Managing Imperfection in Enterprise Models. p:201-210. Ulm, Germany. (2014).
            9. Florez Hector, Sanchez Mario, Villalobos Jorge. Supporting Drafts for Enterprise Modeling. p:200-206. Pereira, Colombia. (2014).
            10. Florez Hector, Sanchez Mario, Villalobos Jorge. Embracing Imperfection in Enterprise Architecture Models. p:8-17. Riga, Latvia. (2013).
            11. Florez Hector. Adapting models in metamodels composition processes. p:96-108. Cartagena, Colombia. (2013).
            12. Florez Hector. Software Product Lines based on Model Transformation Chains. Orlando, United States. (2013).

          Mobile applications in business contexts

          By creating mobile business applications, specific business solutions are created. Furthermore, such applications contribute to the generation of new enterprises

          • Start Date: 2014-01-01
          • Authors
            • Hector Florez
            • Daniel Sanchez
          • Software
            • Black Jack
            • ARtesanias App
            • TelApp
            • BlackJack App
          • Publications
                • Journal Papers
                  1. Wanumen Luis, Florez Hector. Architectural Approaches for Phonemes Recognition Systems. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:267-279. (2018).
                  2. Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
                  3. Joya Juan, Florez Hector. Communication of Mobile Devices through Bluetooth Technology. Vínculos. ISSN:1794-211X. vol:11 (2). p:92-98. (2014).
                • Academic Conferences
                  1. Wanumen Luis, Florez Hector. Architectural Approaches for Phonemes Recognition Systems. p:267-279. Bogota, Colombia. (2018).
                  2. Sanchez Daniel, Florez Hector. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
                  3. Joya Juan, Prieto Karen, Florez Hector. Comunicación Síncrona Mediante Arquitectura Orientada a Servicios para Aplicaciones en Dispositivos . p:422-427. Cartagena, Colombia. (2015).
                  4. Rincon Sebastian, Cardenas Ivan, Florez Hector. M-Commerce basado en Realidad Aumentada. p:284-289. Cartagena, Colombia. (2015).
                  5. Gonzalez Angela, Barrera Ricardo, Florez Hector. M-Marketplaces para la Comercialización de Productos y Servicios. p:290-294. Cartagena, Colombia. (2015).

                © ITI
                2013 - 2020