Grupo de Investigación ITI



Soportado por:
Aplicaciones bioinformaticas para el análisis de microorganismos

El proyecto de aplicaciones bioinformaticas para el análisis de microorganismos está enfocado a realizar análisis computacional de mutaciones del virus de la hepatitis C (VHC) asociados a resistencia a los antivirales de acción directa (AAD). La infección crónica por el VHC sigue siendo un grave problema de salud pública a nivel mundial, afectando a 200 millones de personas y ocasionando unas 10.000 muertes al año. Por tanto es importante determinar la variabilidad del VHC en los genes NS3, NS5A y NS5B, diana de AAD, para poder determinar su posible impacto en el tratamiento con nuevos AAD en pacientes infectados con VHC, prevenir potenciales fallos terapéuticos y optimizar los futuros regímenes terapéuticos, escogiendo los AAD más adecuados para cada paciente.

  • Año de Inicio: 2013-01-01
  • Autores
    • Hector Florez
    • Karina Salvatierra
  • Software
    • PSSA
    • BMA
  • Publicaciones

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        • Artículos en Revista
          1. Sweta Singh, Hector Florez. Coronavirus disease 2019 drug discovery through molecular docking. F1000 Research. ISSN:2046-1402. vol:9(502). p:1-9. (2020).
          2. Hector Florez, Sweta Singh. Online dashboard and data analysis approach for assessing COVID-19 case and death data. F1000 Research. ISSN:2046-1402. vol:9(570). p:1-9. (2020).
          3. Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. Communications in Computer and Information Science. ISSN:1865-0929. vol:1051. p:3-14. (2019).
          4. . . . ISSN:. vol:. p:. ().
          5. . . . ISSN:. vol:. p:. ().
          6. Karina Salvatierra, Hector Florez . Bioinformatics Approach to Analyze Influenza Viruses. Communications in Computer and Information Science. ISSN:1865-0929. vol:916. p:442-452. (2018).
          7. Mauro Guardiola, Karina Salvatierra, Hector Florez. Computer analysis of resistance mutations to HCV NS5A antivirals. International Journal of Infectious Diseases. ISSN:1201-9712. vol:73S. p:382-383. (2018).
          8. Karina Salvatierra, Hector Florez. Computational analysis of resistance mutations in the hepatitis C virus. Vínculos. ISSN:1794-211X. vol:15. p:27-33. (2018).
          9. Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. Communications in Computer and Information Science. ISSN:1865-0929. vol:742. p:96-107. (2017).
          10. . . . ISSN:. vol:. p:. ().
          11. Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. Information. ISSN:1343-4500. vol:20 (9A). p:6665-6672. (2017).
          12. . . . ISSN:. vol:. p:. ().
          13. . . . ISSN:. vol:. p:. ().
          14. Karina Salvatierra, Hector Florez. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. F1000 Research. ISSN:2046-1402. vol:6 (21). p:1-8. (2017).
          15. Karina Salvatierra, Hector Florez. Prevalence of hepatitis B and C infections in hemodialysis patients. F1000 Research. ISSN:2046-1402. vol:5 (1910). p:1-6. (2016).
          16. Karina Salvatierra, Hector Florez. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. F1000 Research. ISSN:2046-1402. vol:5 (1141). p:1-9. (2016).
          17. . . . ISSN:. vol:. p:. ().
          18. . . . ISSN:. vol:. p:. ().
          19. Karina Salvatierra, Hector Florez. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. Infectio. ISSN:0123-9392. vol:20 (3). p:130-137. (2015).
          20. . . . ISSN:. vol:. p:. ().
          21. Karina Salvatierra, Hector Florez. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. Biomédica. ISSN:0120-4157. vol:35. p:125. (2015).
        • Conferencias Académicas
          1. Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. p:3-14. Madrid, España. (2019).
          2. . . . ().
          3. . . . ().
          4. Karina Salvatierra, Hector Florez . Bioinformatics Approach to Analyze Influenza Viruses. p:442-452. Medellin, Colombia. (2018).
          5. Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. p:96-107. Cartagena, Colombia. (2017).
          6. . . . ().
          7. . . . ().
          8. . . . ().
          9. Hector Florez, Karina Salvatierra. A Tool for Analyzing Mutations in Biomedical Microorganisms. p:25-33. Orlando, Estados Unidos. (2017).
          10. . . . ().
          11. . . . ().
          12. . . . ().

        Diseño de soluciones en el contexto de ingenía dirigida por modelos

        Por medio de la creación de metamodelos y transformaciones modelo a modelo y modelo a texto, se desea crear proyectos de software de forma semiautomática, a partir de la creación de un único modelo conceptual.

        • Año de Inicio: 2013-01-01
        • Autores
          • Hector Florez
          • Daniel Sanchez
          • Oscar Mendez
        • Software
          • CFP
          • RIS
          • DevPHP
          • RIWA
          • PHPGen
        • Publicaciones
          • Libros
            1. Hector Florez. Sistemas Digitales. Ediciones de la U. ISSN:978-958-762-190-7. 2014.
          • Capítulos de Libro
            1. Hector Florez. Human Factors in Automated Analysis for Enterprise Models. IGI Global. ISSN:180619075135. 2019.
            2. Hector Florez, Mario Sanchez, Jorge Villalobos. Drafting Enterprise Models. IGI Global. ISSN:9781522555223. 2019.

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          • Artículos en Revista
            1. Hector Florez, Edwarth Garcia, Deisy Muñoz . Automatic Code Generation System for Transactional Web Applications. Lecture Notes in Computer Science. ISSN:0302-9743. vol:11623. p:436-451. (2019).
            2. Hector Florez, Marcelo Leon. Model Driven Engineering Approach to Configure Software Reusable Components. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:352-363. (2018).
            3. Daniel Sanchez, Hector Florez. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
            4. Daniel Sanchez, Oscar Mendez, Hector Florez . An Approach of a Framework to Create Web Applications. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:341-352. (2018).
            5. Hector Florez, Mario Sanchez, Jorge Villalobos. Analysis of Imprecise Enterprise Models. Lecture Notes in Business Information Processing. ISSN:1865-1348. vol:248. p:349-364. (2016).
            6. Hector Florez, Mario Sanchez, Jorge Villalobos. A Catalog of Automated Analysis Methods for Enterprise Models. SpringerPlus. ISSN:2193-1801. vol:5 (406). p:1-24. (2016).
            7. Hector Florez. Metamodels composition strategy for the model driven engineering context. Tecnura. ISSN:0123-921X. vol:44. p:109-120. (2015).
            8. Paola Gómez, Mario Sánchez, Hector Florez, Jorge Villalobos. An Approach to the Co-creation of Models and Metamodels in Enterprise Architecture Projects. Journal of Object Technology. ISSN:1660-1769. vol:13 (3). p:1-29. (2014).
            9. Hector Florez, Mario Sanchez, Jorge Villalobos. Embracing Imperfection in Enterprise Architecture Models. CEUR Workshops Proceedings. ISSN:1613-0073. vol:1023. p:8-17. (2013).
            10. Hector Florez. Adapting models in metamodels composition processes. Vínculos. ISSN:1794-211X. vol:10 (1). p:96-108. (2013).
            11. . . . ISSN:. vol:. p:. ().
          • Conferencias Académicas
            1. Hector Florez, Edwarth Garcia, Deisy Muñoz . Automatic Code Generation System for Transactional Web Applications. p:436-451. San Petesburgo, Rusia. (2019).
            2. Hector Florez, Marcelo Leon. Model Driven Engineering Approach to Configure Software Reusable Components. p:352-363. Bogotá, Colombia. (2018).
            3. Daniel Sanchez, Hector Florez. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
            4. Daniel Sanchez, Oscar Mendez, Hector Florez . An Approach of a Framework to Create Web Applications. p:341-352. Melbourne, Australia. (2018).
            5. Daniel Sanchez, Oscar Mendez, Hector Florez . Applying the 3-layer Model in the Construction of a Framework to Create Web Applications. p:364-369. Orlando, Estados Unidos. (2017).
            6. Hector Florez, Mario Sanchez, Jorge Villalobos. Analysis of Imprecise Enterprise Models. p:349-364. Ljubljana, Eslovenia. (2016).
            7. Hector Florez, Mario Sanchez, Jorge Villalobos. Extensible Model-based Approach for Supporting Automatic Enterprise Analysis. p:32-41. Ulm, Alemania. (2014).
            8. Hector Florez, Mario Sanchez, Jorge Villalobos. iArchiMate: A Tool for Managing Imperfection in Enterprise Models. p:201-210. Ulm, Alemania. (2014).
            9. Hector Florez, Mario Sanchez, Jorge Villalobos. Supporting Drafts for Enterprise Modeling. p:200-206. Pereira, Colombia. (2014).
            10. Hector Florez, Mario Sanchez, Jorge Villalobos. Embracing Imperfection in Enterprise Architecture Models. p:8-17. Riga, Letonia. (2013).
            11. . . . ().

          Aplicaciones móviles en contextos empresarial

          Mediante la creación de aplicaciones móviles empresariales se crean soluciones de negocio específicas. Además, dichas aplicaciones contribuyen a la generación de nuevas empresas

          • Año de Inicio: 2014-01-01
          • Autores
            • Hector Florez
            • Daniel Sanchez
          • Software
            • Black Jack
            • ARtesanias App
            • TelApp
            • BlackJack App
          • Publicaciones

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                • Artículos en Revista
                  1. Luis Wanumen, Hector Florez. Architectural Approaches for Phonemes Recognition Systems. Communications in Computer and Information Science. ISSN:1865-0929. vol:942. p:267-279. (2018).
                  2. Daniel Sanchez, Hector Florez. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. Lecture Notes in Computer Science. ISSN:0302-9743. vol:10963. p:353-364. (2018).
                  3. . . . ISSN:. vol:. p:. ().
                  4. . . . ISSN:. vol:. p:. ().
                  5. . . . ISSN:. vol:. p:. ().
                  6. . . . ISSN:. vol:. p:. ().
                • Conferencias Académicas
                  1. Luis Wanumen, Hector Florez. Architectural Approaches for Phonemes Recognition Systems. p:267-279. Bogotá, Colombia. (2018).
                  2. Daniel Sanchez, Hector Florez. Model Driven Engineering Approach to Manage Peripherals in Mobile Devices. p:353-364. Melbourne, Australia. (2018).
                  3. . . . ().
                  4. . . . ().
                  5. . . . ().
                  6. . . . ().


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