El proyecto de aplicaciones bioinformaticas para el análisis de microorganismos está enfocado a realizar análisis computacional de mutaciones del virus de la hepatitis C (VHC) asociados a resistencia a los antivirales de acción directa (AAD). La infección crónica por el VHC sigue siendo un grave problema de salud pública a nivel mundial, afectando a 200 millones de personas y ocasionando unas 10.000 muertes al año. Por tanto es importante determinar la variabilidad del VHC en los genes NS3, NS5A y NS5B, diana de AAD, para poder determinar su posible impacto en el tratamiento con nuevos AAD en pacientes infectados con VHC, prevenir potenciales fallos terapéuticos y optimizar los futuros regímenes terapéuticos, escogiendo los AAD más adecuados para cada paciente.
- Año de Inicio: 2013-01-01
- Autores
- Hector Florez
- Karina Salvatierra
- Software
- Publicaciones
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- Artículos en Revista
- Sweta Singh, Hector Florez. Coronavirus disease 2019 drug discovery through molecular docking. F1000 Research. ISSN:2046-1402. vol:9(502). p:1-9. (2020).
- Hector Florez, Sweta Singh. Online dashboard and data analysis approach for assessing COVID-19 case and death data. F1000 Research. ISSN:2046-1402. vol:9(570). p:1-9. (2020).
- Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. Communications in Computer and Information Science. ISSN:1865-0929. vol:1051. p:3-14. (2019).
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- Karina Salvatierra, Hector Florez . Bioinformatics Approach to Analyze Influenza Viruses. Communications in Computer and Information Science. ISSN:1865-0929. vol:916. p:442-452. (2018).
- Mauro Guardiola, Karina Salvatierra, Hector Florez. Computer analysis of resistance mutations to HCV NS5A antivirals. International Journal of Infectious Diseases. ISSN:1201-9712. vol:73S. p:382-383. (2018).
- Karina Salvatierra, Hector Florez. Computational analysis of resistance mutations in the hepatitis C virus. Vínculos. ISSN:1794-211X. vol:15. p:27-33. (2018).
- Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. Communications in Computer and Information Science. ISSN:1865-0929. vol:742. p:96-107. (2017).
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- Florez Hector, Salvatierra Karina. Bioinformatics Study of Mutations of Resistance to Antivirals in the NS5A Gen of HCV. Information. ISSN:1343-4500. vol:20 (9A). p:6665-6672. (2017).
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- Karina Salvatierra, Hector Florez. Pathogen Sequence Signature Analysis (PSSA): A software tool for analyzing sequences to identify microorganism genotypes. F1000 Research. ISSN:2046-1402. vol:6 (21). p:1-8. (2017).
- Karina Salvatierra, Hector Florez. Prevalence of hepatitis B and C infections in hemodialysis patients. F1000 Research. ISSN:2046-1402. vol:5 (1910). p:1-6. (2016).
- Karina Salvatierra, Hector Florez. Biomedical Mutation Analysis (BMA): A software tool for analyzing mutations associated with antiviral resistance. F1000 Research. ISSN:2046-1402. vol:5 (1141). p:1-9. (2016).
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- Karina Salvatierra, Hector Florez. Análisis del Virus de la Hepatitis C en pacientes en hemodiálisis. Infectio. ISSN:0123-9392. vol:20 (3). p:130-137. (2015).
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- Karina Salvatierra, Hector Florez. Análisis Computacional de Mutaciones de Resistencias a Inhibidores de la Proteasa NS3 Y Polimerasa NS5B del Virus de la Hepatitis C. Biomédica. ISSN:0120-4157. vol:35. p:125. (2015).
- Conferencias Académicas
- Karina Salvatierra, Marcos Vera, Hector Florez. Bioinformatics Methods to Discover Antivirals Against Zika Virus. p:3-14. Madrid, España. (2019).
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- Karina Salvatierra, Hector Florez . Bioinformatics Approach to Analyze Influenza Viruses. p:442-452. Medellin, Colombia. (2018).
- Florez Hector, Salvatierra Karina. A Web-Based Approach for Analyzing Microorganism Sequences. p:96-107. Cartagena, Colombia. (2017).
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- Hector Florez, Karina Salvatierra. A Tool for Analyzing Mutations in Biomedical Microorganisms. p:25-33. Orlando, Estados Unidos. (2017).
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